Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 10/20 | 0.41 |
| ▸ | FEN1 | P39748 | 10/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.37 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21644913 | 0.81 | FFAR1 (0.43) | ALOX5APFEN1FFAR1CHRNB2CHRNB4 | |
| SCHEMBL20103176 | 0.81 | FFAR1 (0.43) | ALOX5APFEN1FFAR1CHRNB2CHRNB4 | |
| SCHEMBL20103177 | 0.81 | FFAR1 (0.43) | ALOX5APFEN1FFAR1CHRNB2CHRNB4 | |
| SCHEMBL28709002 | 0.76 | FFAR1 (0.39) | ALOX5APFEN1FFAR1FFAR4TLR9 | |
| SCHEMBL20103605 | 0.73 | FFAR1 (0.40) | FFAR1CHRNB2CHRNB4CHRNA4CHRNA2 | |
| SCHEMBL20103281 | 0.70 | PTGDR2 (0.52) | FFAR1HTR2A | |
| SCHEMBL20103378 | 0.70 | CNR2 (0.34) | FFAR1FFAR4 | |
| SCHEMBL20103485 | 0.70 | FFAR1 (0.42) | FFAR1FFAR4TLR9TLR8TLR7 | |
| SCHEMBL28115039 | 0.68 | TLR9 (0.42) | TLR9TLR8TLR7 | |
| SCHEMBL21644893 | 0.68 | FFAR1 (0.35) | FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081047-A1 | CYCLOHEXYL GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |