Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5251694 | 1.00 | KDM4E (0.42) | KDM4EPOLBL3MBTL1MCL1MAPK1 | |
| SCHEMBL6622419 | 0.93 | — | — | |
| SCHEMBL9184577 | 0.83 | — | — | |
| SCHEMBL10284785 | 0.80 | SIRT1 (0.37) | KDM4EPOLBL3MBTL1MCL1MAPK1 | |
| SCHEMBL15414620 | 0.74 | KDM4E (0.43) | KDM4EPOLBL3MBTL1MCL1MAPK1 | |
| SCHEMBL3553694 | 0.74 | MCL1 (0.60) | KDM4EPOLBL3MBTL1MCL1MAPK1 | |
| SCHEMBL612494 | 0.74 | MCL1 (0.60) | KDM4EPOLBL3MBTL1MCL1MAPK1 | |
| SCHEMBL7353241 | 0.73 | MCL1 (0.58) | KDM4EPOLBL3MBTL1MCL1MAPK1 | |
| SCHEMBL22570984 | 0.73 | — | — | |
| SCHEMBL3076529 | 0.73 | KDM4E (0.42) | KDM4EPOLBL3MBTL1MCL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3110810-B1 | PYRAZOLE AMIDE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2018-05-02 | — | — | EP | disclosed |