Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7569971 | 0.75 | CYP19A1 (0.40) | CYP19A1LRRK2 | |
| SCHEMBL12450406 | 0.70 | CYP19A1 (0.56) | CYP19A1 | |
| SCHEMBL6799273 | 0.67 | GAA (0.61) | HDAC6MEN1ALDH1A1POLBGAA | |
| SCHEMBL3296253 | 0.67 | FFAR1 (0.50) | HDAC1MEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL3298978 | 0.66 | PPARA (0.51) | MEN1ALDH1A1GAAMAPTBLM | |
| SCHEMBL6795311 | 0.66 | MAPT (0.80) | MEN1ALDH1A1POLBGAAMAPT | |
| SCHEMBL10055010 | 0.66 | MAPT (0.80) | MEN1ALDH1A1POLBGAAMAPT | |
| SCHEMBL20105115 | 0.65 | CLK4 (0.47) | HDAC1HDAC8HDAC6MEN1ALDH1A1 | |
| SCHEMBL7575275 | 0.65 | PELI1 (0.40) | LRRK2 | |
| SCHEMBL10629429 | 0.64 | ESR2 (0.52) | LRRK2CYP3A4CYP2C9CYP2C19ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470512-B1 | AROMATASE INHIBITOR | ESTRYX PHARMA LTD (GB) | 2018-05-02 | — | — | EP | disclosed |