Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.33 |
| ▸ | PDE1A | P54750 | 4/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PDE8A | O60658 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17314102 | 0.86 | YTHDC1 (0.40) | YTHDC1CYP11B2 | |
| SCHEMBL15931509 | 0.86 | YTHDC1 (0.40) | YTHDC1CYP11B2 | |
| SCHEMBL17314970 | 0.86 | YTHDC1 (0.38) | YTHDC1CYP11B2 | |
| SCHEMBL15931226 | 0.86 | YTHDC1 (0.40) | YTHDC1CYP11B2 | |
| SCHEMBL17314940 | 0.86 | YTHDC1 (0.40) | YTHDC1CYP11B2 | |
| SCHEMBL17314971 | 0.86 | YTHDC1 (0.38) | YTHDC1CYP11B2 | |
| SCHEMBL15942192 | 0.85 | YTHDC1 (0.37) | YTHDC1CYP11B2 | |
| SCHEMBL15921610 | 0.84 | YTHDC1 (0.39) | YTHDC1CYP11B2 | |
| SCHEMBL15931214 | 0.83 | YTHDC1 (0.41) | YTHDC1 | |
| SCHEMBL17314945 | 0.83 | YTHDC1 (0.41) | YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |