Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | TPH1 | P17752 | 3/20 | 0.46 |
| ▸ | TPH2 | Q8IWU9 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15923850 | 0.82 | GAA (0.56) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL15924216 | 0.81 | MEN1 (0.55) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL15923656 | 0.76 | KMT2A (0.53) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL15924451 | 0.72 | KMT2A (0.58) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL16363970 | 0.68 | ATM (0.55) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2035525 | 0.67 | F2R (0.48) | MEN1KMT2APOLB | |
| SCHEMBL555082 | 0.66 | BRAF (0.72) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL23202390 | 0.65 | MEN1 (0.47) | ALDH1A1MEN1KMT2APOLBTPH1 | |
| SCHEMBL16076188 | 0.65 | BRDT (0.71) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL22800966 | 0.65 | ALDH1A1 (0.62) | GAAALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |