Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21243824 | 1.00 | NTRK1 (0.69) | NTRK1JAK2 | |
| SCHEMBL20105863 | 1.00 | NTRK1 (0.69) | NTRK1JAK2 | |
| SCHEMBL21243827 | 0.92 | NTRK1 (0.65) | NTRK1JAK2 | |
| SCHEMBL20106510 | 0.92 | NTRK1 (0.65) | NTRK1JAK2 | |
| SCHEMBL23051018 | 0.89 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL20106142 | 0.89 | NTRK1 (0.59) | NTRK1JAK2 | |
| SCHEMBL2599208 | 0.88 | NTRK1 (0.72) | NTRK1JAK2 | |
| SCHEMBL2599206 | 0.88 | NTRK1 (0.72) | NTRK1JAK2 | |
| SCHEMBL933659 | 0.88 | NTRK1 (0.81) | NTRK1JAK2 | |
| SCHEMBL933657 | 0.88 | NTRK1 (0.81) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091486-B2 | Process for the preparation of pyrazolo[1,5-a]pyrimidines and salts thereof | ARRAY BIOPHARMA, INC (US) | 2021-08-17 | — | — | US | disclosed |
| US-11091486-B2 | Process for the preparation of pyrazolo[1,5-a]pyrimidines and salts thereof | ARRAY BIOPHARMA, INC (US) | 2021-08-17 | — | — | US | disclosed |
| EP-3700576-A1 | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR | Array Biopharma Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| US-20200216451-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | ARRAY BIOPHARMA, INC. | 2020-07-09 | — | — | US | disclosed |
| US-20200216451-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | ARRAY BIOPHARMA, INC. | 2020-07-09 | — | — | US | disclosed |
| US-20190247398-A1 | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR | LOXO ONCOLOGY, INC. | 2019-08-15 | — | — | US | disclosed |
| US-20190247398-A1 | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR | LOXO ONCOLOGY, INC. | 2019-08-15 | — | — | US | disclosed |
| WO-2019005796-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | ZHAO QIAN (US) | 2019-01-03 | — | — | WO | disclosed |
| WO-2018081417-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | ZHAO QIAN (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190247398-A1 | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR | DMPK, TTK, GAK | NTRK1 28/4885JAK2 365/4885 |
| US-11091486-B2 | Process for the preparation of pyrazolo[1,5-a]pyrimidines and salts thereof | DPYD, TYMP, UMPS | NTRK1 4624/4885JAK2 451/4885 |
| US-20200216451-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | DPYD, TYMP, UMPS | NTRK1 4624/4885JAK2 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.