Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 16/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20108206 | 0.87 | DHODH (0.49) | DHODH | |
| SCHEMBL21853424 | 0.85 | DHODH (0.66) | DHODH | |
| SCHEMBL21853426 | 0.85 | DHODH (0.66) | DHODH | |
| SCHEMBL20107619 | 0.83 | DHODH (0.46) | DHODHCYP1A2CYP2C9KDM4EALDH1A1 | |
| SCHEMBL21853408 | 0.81 | DHODH (0.66) | DHODH | |
| SCHEMBL28953480 | 0.81 | DHODH (0.51) | DHODH | |
| SCHEMBL29816492 | 0.81 | DHODH (0.66) | DHODH | |
| SCHEMBL20108205 | 0.81 | DHODH (0.66) | DHODH | |
| SCHEMBL20107970 | 0.79 | KDM4E (0.49) | DHODHCYP1A2CYP2C9KDM4EALDH1A1 | |
| SCHEMBL20107762 | 0.79 | DHODH (0.80) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532468-B1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AG (DE) | 2022-03-23 | — | — | EP | disclosed |
| WO-2018077923-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |