Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 4/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27427354 | 0.86 | CYP11B1 (0.42) | ARXDH | |
| SCHEMBL12656324 | 0.82 | ALDH1A1 (0.44) | ALDH1A1HPGDARXDH | |
| SCHEMBL28419965 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HPGDARXDH | |
| SCHEMBL8202547 | 0.78 | ALDH1A1 (0.49) | ALDH1A1HPGDARXDH | |
| SCHEMBL2774024 | 0.78 | HPGD (0.49) | ALDH1A1HPGDARXDH | |
| SCHEMBL23862114 | 0.78 | AAK1 (0.37) | AR | |
| SCHEMBL878726 | 0.77 | AAK1 (0.39) | ALDH1A1HPGD | |
| SCHEMBL20107968 | 0.77 | AR (0.39) | ALDH1A1AR | |
| SCHEMBL18466878 | 0.76 | PDE3B (0.43) | HPGD | |
| SCHEMBL20107665 | 0.75 | CYP2D6 (0.38) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532468-B1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AG (DE) | 2022-03-23 | — | — | EP | disclosed |
| WO-2018077923-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |