SCHEMBL2010769

SCHEMBL2010769

O=CC(c1ccc(F)cc1)c1cc(Br)ccn1

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 5/20 0.36
S1PR3 Q99500 5/20 0.36
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CYP19A1 P11511 3/20 0.32
EGFR P00533 1/20 0.30
HDAC3 O15379 1/20 0.30
HDAC4 P56524 1/20 0.30
HDAC1 Q13547 1/20 0.30
HDAC7 Q8WUI4 1/20 0.30
HDAC2 Q92769 1/20 0.30
HDAC10 Q969S8 1/20 0.30
HDAC11 Q96DB2 1/20 0.30
HDAC8 Q9BY41 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30
HDAC9 Q9UKV0 1/20 0.30
HDAC5 Q9UQL6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2010819 0.85 S1PR1 (0.38) S1PR1S1PR3KDM4EALDH1A1SMN1; SMN2
SCHEMBL2008368 0.81 S1PR1 (0.34) S1PR1S1PR3KDM4EALDH1A1SMN1; SMN2
SCHEMBL8133903 0.77 HDAC1 (0.31) EGFRHDAC3HDAC4HDAC1HDAC7
SCHEMBL30637612 0.74 HDAC3 (0.41) S1PR1S1PR3KDM4EALDH1A1SMN1; SMN2
SCHEMBL6189088 0.73 PTGDR2 (0.36) KDM4ECYP19A1
SCHEMBL1555509 0.73 TRPV1 (0.34)
SCHEMBL3540663 0.72 IDO1 (0.41) ALDH1A1SMN1; SMN2HDAC3HDAC4HDAC1
SCHEMBL20746229 0.72 ALDH1A1 (0.40) S1PR1S1PR3KDM4EALDH1A1SMN1; SMN2
SCHEMBL7394777 0.71 PTGDR2 (0.38)
SCHEMBL7124623 0.71 PTGDR2 (0.38) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2507238-A1 DIPHENYL-PYRAZOLOPYRDINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF AS NUCLEAR RECEPTOR NOT MODULATORS SANOFI (FR) 2012-10-10 EP disclosed
EP-2477988-A1 ACETYLENE DERIVATIVES OF 5-PHENYL-PYRAZOLOPYRIDINE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-07-25 EP disclosed
EP-2477990-A1 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-07-25 EP disclosed
WO-2011067544-A1 DIPHENYL-PYRAZOLOPYRDINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF AS NUCLEAR RECEPTOR NOT MODULATORS SANOFI-AVENTIS (FR) 2011-06-09 WO disclosed
WO-2011033230-A1 5-PHENYL PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-03-24 WO disclosed