Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20107685 | 0.96 | DHODH (0.51) | DHODHKDM4ETLR7 | |
| SCHEMBL20107970 | 0.90 | KDM4E (0.49) | DHODHKDM4EMEN1MAPTHTT | |
| SCHEMBL25910497 | 0.87 | DHODH (0.52) | DHODHTLR7 | |
| SCHEMBL20107619 | 0.85 | DHODH (0.46) | DHODHKDM4E | |
| SCHEMBL20107915 | 0.83 | TLR7 (0.49) | DHODHKDM4ETLR7 | |
| SCHEMBL29816423 | 0.81 | DHODH (0.69) | DHODH | |
| SCHEMBL21853474 | 0.81 | DHODH (0.69) | DHODH | |
| SCHEMBL20107899 | 0.81 | DHODH (0.69) | DHODH | |
| SCHEMBL20107926 | 0.81 | DHODH (0.53) | DHODHHTT | |
| SCHEMBL21471173 | 0.80 | DHODH (0.50) | DHODHKDM4ETLR7NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532468-B1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AG (DE) | 2022-03-23 | — | — | EP | disclosed |
| WO-2018077923-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |