Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | PLK1 | P53350 | 6/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30427708 | 0.88 | PLK1 (0.44) | PLK1PLK3NEK2 | |
| SCHEMBL29453063 | 0.87 | PLK1 (0.51) | PLK1PLK3NEK2 | |
| SCHEMBL29536039 | 0.87 | PLK1 (0.51) | PLK1PLK3NEK2 | |
| SCHEMBL3963311 | 0.87 | PLK1 (0.51) | PLK1PLK3NEK2 | |
| SCHEMBL1370903 | 0.81 | KMT2A (0.51) | KMT2APLK1PLK3MEN1CYP1A2 | |
| SCHEMBL25267168 | 0.81 | PLK1 (0.49) | PLK1PLK3NEK2 | |
| SCHEMBL2977455 | 0.81 | PLK1 (0.49) | PLK1PLK3NEK2 | |
| SCHEMBL30426721 | 0.81 | PLK1 (0.49) | PLK1PLK3NEK2 | |
| Hydrochloric Acid SCHEMBL3118930 | 0.80 | PLK1 (0.49) | PLK1PLK3NEK2 | |
| SCHEMBL4777503 | 0.79 | PLK1 (0.49) | PLK1PLK3NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081719-A1 | SMALL MOLECULE INHIBITORS OF NEK2 AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2018-05-03 | — | — | WO | disclosed |