Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.51 |
| ▸ | NEK2 | P51955 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | GRK4 | P32298 | 1/20 | 0.46 |
| ▸ | TIE1 | P35590 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963311 | 1.00 | PLK1 (0.51) | PLK1PLK3NEK2CYP3A4CYP2C9 | |
| SCHEMBL29536039 | 1.00 | PLK1 (0.51) | PLK1PLK3NEK2CYP3A4CYP2C9 | |
| SCHEMBL30427708 | 0.89 | PLK1 (0.44) | PLK1PLK3NEK2CYP3A4CYP2C9 | |
| SCHEMBL20108162 | 0.87 | KMT2A (0.48) | PLK1PLK3NEK2 | |
| SCHEMBL4632897 | 0.76 | NEK2 (0.40) | PLK1PLK3NEK2CYP3A4CYP2C9 | |
| SCHEMBL4777503 | 0.76 | PLK1 (0.49) | PLK1PLK3NEK2CYP3A4CYP2C9 | |
| SCHEMBL2991160 | 0.74 | PLK1 (0.50) | PLK1PLK3NEK2CYP3A4CYP2C9 | |
| SCHEMBL29915268 | 0.72 | MAOB (0.57) | PLK1PLK3NEK2PDGFRBKIT | |
| SCHEMBL25267168 | 0.72 | PLK1 (0.49) | PLK1PLK3NEK2CYP3A4CYP2C9 | |
| SCHEMBL2977455 | 0.72 | PLK1 (0.49) | PLK1PLK3NEK2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4204020-A1 | METHOD OF TREATING PSMA-EXPRESSING CANCERS | Advanced Accelerator Applications International S.A. (CH) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022043558-A1 | METHOD OF TREATING PSMA-EXPRESSING CANCERS | ADVANCED ACCELERATOR APPLICATIONS INTERNATIONAL SA (CH) | 2022-03-03 | — | — | WO | disclosed |