Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13519529 | 0.63 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL9436253 | 0.63 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1LMNAALDH1A1MAPT | |
| SCHEMBL24302594 | 0.57 | SMN1; SMN2 (0.33) | HSP90AA1HSP90AB1LMNAALDH1A1MAPT | |
| SCHEMBL23640361 | 0.57 | SMN1; SMN2 (0.33) | HSP90AA1HSP90AB1LMNAALDH1A1MAPT | |
| SCHEMBL20281295 | 0.57 | LMNA (0.36) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL17733547 | 0.55 | NAMPT (0.33) | HSP90AA1HSP90AB1LMNAALDH1A1MAPT | |
| SCHEMBL7139219 | 0.55 | LMNA (0.52) | LMNAALDH1A1MAPTHTTL3MBTL1 | |
| SCHEMBL2728856 | 0.55 | LMNA (0.58) | LMNAALDH1A1MAPTHTTRAB9A | |
| SCHEMBL3791417 | 0.55 | LMNA (0.58) | LMNAALDH1A1MAPTHTTRAB9A | |
| SCHEMBL13591827 | 0.54 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964635-B1 | ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-05-02 | — | — | EP | disclosed |