Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24488779 | 0.92 | HDAC6 (0.77) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL21698849 | 0.91 | HDAC6 (0.74) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL21698937 | 0.90 | HDAC6 (0.75) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL24727542 | 0.81 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL18822147 | 0.81 | HDAC6 (0.53) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL2227104 | 0.78 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| Ricolinostat SCHEMBL574580 | 0.77 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| Citarinostat SCHEMBL2225863 | 0.77 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL18347205 | 0.77 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL2226158 | 0.77 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081585-A1 | PHARMACEUTICAL COMBINATIONS COMPRISING A HISTONE DEACETYLASE INHIBITOR AND AN AURORA KINASE INHIBITOR AND METHODS OF USE THEREOF | ACETYLON PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |