Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21698937 | 0.81 | HDAC6 (0.75) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL20109699 | 0.81 | HDAC6 (0.63) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL24488779 | 0.81 | HDAC6 (0.77) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL21698849 | 0.79 | HDAC6 (0.74) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL16646754 | 0.79 | HDAC6 (0.76) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL24727542 | 0.76 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL16644092 | 0.72 | HDAC6 (0.73) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL19710836 | 0.70 | HDAC6 (0.69) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL19710750 | 0.70 | HDAC6 (0.66) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL2225248 | 0.70 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017075192-A1 | HDAC INHIBITORS FOR THE TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY | ACETYLON PHARMACEUTICALS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |