Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20109830 | 0.88 | KMT2A (0.53) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL14117419 | 0.87 | KMT2A (0.58) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL10268480 | 0.84 | KMT2A (0.55) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL1690607 | 0.81 | KMT2A (0.53) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL17790194 | 0.81 | KMT2A (0.53) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL11913144 | 0.80 | HPGD (0.74) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL14039541 | 0.79 | KMT2A (0.50) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL17119847 | 0.78 | HSD17B1 (0.57) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL1196990 | 0.77 | HPGD (0.51) | KMT2AMEN1HPGDTDP1HSD17B1 | |
| SCHEMBL12806220 | 0.75 | MAOB (0.51) | KMT2AMEN1NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534152-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-02 | — | — | EP | disclosed |