Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.59 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014646 | 0.86 | HCRTR1 (0.56) | HCRTR1HCRTR2NPC1RAB9APOLB | |
| SCHEMBL2013021 | 0.85 | HCRTR1 (0.57) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2014309 | 0.83 | HCRTR1 (0.57) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2013002 | 0.83 | HCRTR1 (0.57) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13139060 | 0.81 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AHDAC8 | |
| SCHEMBL2011910 | 0.81 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2010539 | 0.80 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2054212 | 0.79 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2015191 | 0.79 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AHDAC8 | |
| SCHEMBL2054210 | 0.79 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |