Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.35 |
| ▸ | IDH1 | O75874 | 6/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | INSR | P06213 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | LTK | P29376 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 2/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.31 |
| ▸ | MERTK | Q12866 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17582993 | 0.88 | ALK (0.36) | ALKIDH1EGFRINSRLCK | |
| SCHEMBL17582769 | 0.87 | ALK (0.35) | ALKIDH1EGFRINSRLCK | |
| SCHEMBL25919584 | 0.83 | MAPT (0.35) | ALKIDH1EGFR | |
| SCHEMBL18779249 | 0.78 | EGFR (0.39) | ALKEGFRINSRLCKLTK | |
| SCHEMBL18779226 | 0.77 | ALK (0.37) | ALKEGFRINSRLCKLTK | |
| SCHEMBL16084230 | 0.76 | EGFR (0.36) | IDH1EGFRCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL17582797 | 0.76 | EGFR (0.34) | ALKIDH1EGFRINSRLCK | |
| SCHEMBL30659118 | 0.76 | EGFR (0.34) | ALKIDH1EGFRINSRLCK | |
| SCHEMBL20209791 | 0.75 | EGFR (0.34) | ALKEGFRINSRLCKLTK | |
| SCHEMBL17583055 | 0.75 | IDH1 (0.37) | ALKIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081825-A1 | BENZOIMIDAZOL-1, 2-YL AMIDES AS KV7 CHANNEL ACTIVATORS | KNOPP BIOSCIENCES LLC (US) | 2018-05-03 | — | — | WO | disclosed |