Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.62 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.62 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539651 | 0.84 | GNAI3 (0.73) | GNAI3GNAO1GNAI1CHEK1AURKA | |
| SCHEMBL28706412 | 0.82 | GNAI3 (0.71) | GNAI3GNAO1GNAI1CHEK1AURKA | |
| SCHEMBL28716339 | 0.82 | GNAI3 (0.71) | GNAI3GNAO1GNAI1CHEK1AURKA | |
| SCHEMBL16403334 | 0.81 | GNAI3 (0.84) | GNAI3GNAO1GNAI1CHRM5CHRM3 | |
| SCHEMBL3875596 | 0.80 | HTT (0.44) | GNAI3GNAO1GNAI1KDM4EALDH1A1 | |
| SCHEMBL18502923 | 0.79 | GNAI3 (0.53) | GNAI3GNAO1GNAI1CHRM5CHRM3 | |
| SCHEMBL4591725 | 0.78 | HTT (0.47) | GNAI3GNAO1GNAI1KDM4EALDH1A1 | |
| SCHEMBL14255477 | 0.77 | CA12 (0.55) | CA2KMT2ACA12CA1CA9 | |
| SCHEMBL15710418 | 0.76 | GNAI3 (0.46) | GNAI3GNAO1GNAI1CHEK1AURKA | |
| SCHEMBL1394575 | 0.76 | GNAI3 (0.49) | GNAI3GNAO1GNAI1CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081530-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-05-03 | — | — | WO | disclosed |