Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21732723 | 0.90 | ACLY (0.33) | CYP2D6KCNH2HRH3ACLY | |
| SCHEMBL12201520 | 0.87 | EPHX2 (0.39) | CYP2D6KCNH2HRH3ACLYEPHX2 | |
| SCHEMBL20111712 | 0.86 | ACLY (0.34) | CYP2D6KCNH2HRH3ACLYDDIT3 | |
| SCHEMBL24477829 | 0.84 | SMYD3 (0.38) | CYP2D6KCNH2HRH3ACLYEPHX2 | |
| SCHEMBL21732859 | 0.84 | MEN1 (0.39) | — | |
| SCHEMBL12384633 | 0.83 | EPHX2 (0.44) | CYP2D6KCNH2HRH3ACLYEPHX2 | |
| SCHEMBL21732864 | 0.80 | ACLY (0.32) | ACLYEPHX2 | |
| SCHEMBL2706991 | 0.80 | CYP2D6 (0.38) | CYP2D6KCNH2HRH3EPHX2 | |
| SCHEMBL21732954 | 0.79 | SMYD3 (0.31) | — | |
| SCHEMBL12040228 | 0.79 | EPHX2 (0.35) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | E-THERAPEUTICS PLC (GB) | 2021-03-30 | — | — | US | disclosed |
| US-20200055847-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2020-02-20 | — | — | US | disclosed |
| WO-2018078360-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | SHH, GLI1, SMO | CYP2D6 4442/4885KCNH2 4799/4885HRH3 901/4885 |
| US-20200055847-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | SHH, GLI1, SMO | CYP2D6 4378/4885KCNH2 4785/4885HRH3 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.