Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31691635 | 0.88 | HPGD (0.44) | USP2SMN1; SMN2HPGDGPR119RECQL | |
| SCHEMBL31691536 | 0.86 | NR1H2 (0.43) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL31691647 | 0.85 | MEN1 (0.48) | USP2SMN1; SMN2HPGDGPR119EPHX1 | |
| SCHEMBL31691545 | 0.84 | DDB1 (0.44) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL56423 | 0.84 | HPGD (0.50) | USP2SMN1; SMN2HPGDGPR119RECQL | |
| SCHEMBL21732786 | 0.83 | NR1H2 (0.41) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL626244 | 0.81 | NR1H2 (0.50) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL4183086 | 0.81 | NR1H2 (0.50) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL20599655 | 0.79 | NR1H2 (0.49) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28063086 | 0.79 | NR1H2 (0.49) | NR1H2DDB1CRBNUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250304575-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | GALAPAGOS NV (BE) | 2025-10-02 | — | — | US | disclosed |
| EP-4519263-A1 | SULFONAMIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Galapagos NV (BE) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023213836-A1 | SULFONAMIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | GALAPAGOS NV (BE) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023213836-A1 | SULFONAMIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | GALAPAGOS NV (BE) | 2023-11-09 | — | — | WO | disclosed |
| WO-2018078360-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250304575-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | SNCA, PSEN2, PSEN1 | NR1H2 451/4885DDB1 3028/4885CRBN 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.