Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.79 |
| ▸ | GAA | P10253 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.60 |
| ▸ | XDH | P47989 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29199947 | 0.98 | RAB9A (0.77) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL892234 | 0.88 | RAB9A (1.00) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL8867051 | 0.87 | RAB9A (0.79) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL15656858 | 0.87 | RAB9A (0.74) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL289112 | 0.87 | SMN1; SMN2 (0.93) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL1327631 | 0.86 | SMN1; SMN2 (1.00) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL8339818 | 0.85 | RAB9A (0.77) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL12970049 | 0.85 | RAB9A (0.77) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL3436647 | 0.85 | RAB9A (0.77) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL14018508 | 0.85 | RAB9A (0.77) | RAB9AKDM4EGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572272-B | Preparation method of febuxostat and aldehyde ester intermediate thereof | 湖北华世通生物医药科技有限公司 | 2024-05-07 | — | — | CN | claimed |
| CN-115572272-A | Preparation method of febuxostat and aldehyde ester intermediate thereof | 湖北华世通生物医药科技有限公司 | 2023-01-06 | — | — | CN | claimed |
| CN-106518802-B | A kind of synthetic method of 2- (3- aldehyde radical -4- hydroxy phenyls) -4- methylthiazole-5-carboxylates | 山东铂源药业有限公司 | 2018-11-09 | — | — | CN | claimed |
| CN-106518802-A | Synthesis method of ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate | 山东铂源药业有限公司 | 2017-03-22 | — | — | CN | claimed |
| CN-104418823-A | Preparation method of febuxostat intermediate | KNOWSHINE SHANGHAI PHARMACHEMICALS INC | 2015-03-18 | — | — | CN | claimed |
| EP-1651624-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES | ABBVIE INC (US) | 2015-03-11 | — | — | EP | claimed |
| CN-101665471-B | Preparation method of febuxostat intermediate | UNIV CHINA PHARMA | 2011-08-10 | — | — | CN | claimed |
| CN-101665471-A | Preparation method of febuxostat intermediate | UNIV CHINA PHARMA | 2010-03-10 | — | — | CN | claimed |
| CN-115572272-B | Preparation method of febuxostat and aldehyde ester intermediate thereof | 湖北华世通生物医药科技有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-115572272-A | Preparation method of febuxostat and aldehyde ester intermediate thereof | 湖北华世通生物医药科技有限公司 | 2023-01-06 | — | — | CN | disclosed |
| CN-109503513-A | A kind of \" one kettle way \" synthetic method of Febustat intermediate | 嘉实（湖南）医药科技有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-109503513-A | A kind of \" one kettle way \" synthetic method of Febustat intermediate | 嘉实（湖南）医药科技有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-109354584-A | The method of one pot process 2- (4- hydroxy phenyl) -4- methyl-1,3-thiazole-5-carboxylic acid ethyl ester | 湖北理工学院 | 2019-02-19 | — | — | CN | disclosed |
| CN-109320474-A | A kind of preparation method of Febustat | 昆明源瑞制药有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-101665471-A | Preparation method of febuxostat intermediate | UNIV CHINA PHARMA | 2010-03-10 | — | — | CN | disclosed |
| CN-101665471-A | Preparation method of febuxostat intermediate | UNIV CHINA PHARMA | 2010-03-10 | — | — | CN | disclosed |
| CN-101374834-A | Compounds and methods for modulating FXR | LILLY CO ELI (US) | 2009-02-25 | — | — | CN | disclosed |
| EP-1651624-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES | Abbott Laboratories (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005012273-A3 | PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES | ABBOTT LAB (US) | 2005-05-12 | — | — | WO | disclosed |
| WO-2005012273-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES | ABBOTT LABORATORIES (US) | 2005-02-10 | — | — | WO | disclosed |