Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | AXL | P30530 | 6/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20111765 | 0.80 | HSD11B1 (0.49) | HSD11B1OPRL1OPRM1OPRK1AXL | |
| SCHEMBL20111759 | 0.80 | HSD11B1 (0.49) | HSD11B1OPRL1OPRM1OPRK1AXL | |
| SCHEMBL21714613 | 0.80 | HSD11B1 (0.49) | HSD11B1OPRL1OPRM1OPRK1AXL | |
| SCHEMBL20111682 | 0.80 | HSD11B1 (0.49) | HSD11B1OPRL1OPRM1OPRK1AXL | |
| SCHEMBL16801704 | 0.74 | KDM4E (0.65) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714171 | 0.74 | HSD11B1 (0.54) | HSD11B1OPRL1OPRM1OPRK1AXL | |
| SCHEMBL21714173 | 0.73 | HSD11B1 (0.54) | HSD11B1OPRL1OPRM1OPRK1AXL | |
| SCHEMBL2267177 | 0.73 | HSD11B1 (0.63) | HSD11B1OPRL1OPRM1OPRK1 | |
| SCHEMBL6158491 | 0.73 | HSD11B1 (0.66) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL14280715 | 0.72 | HSD11B1 (0.60) | HSD11B1OPRL1OPRM1OPRK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078360-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2018-05-03 | — | — | WO | disclosed |