Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20112961 | 0.87 | GRM7 (0.58) | GRM7P2RX7SCN9ASCN5AKCNH2 | |
| SCHEMBL20112966 | 0.86 | GRM7 (0.55) | GRM7P2RX7SCN9ASCN5AKCNH2 | |
| SCHEMBL20112967 | 0.84 | GRM7 (0.58) | GRM7P2RX7SCN9ASCN5AKCNH2 | |
| SCHEMBL20113084 | 0.84 | GRM7 (0.66) | GRM7SCN9ASCN5AKCNH2KMT2A | |
| SCHEMBL20112956 | 0.83 | GRM7 (0.62) | GRM7P2RX7SCN9ASCN5AKCNH2 | |
| SCHEMBL20112960 | 0.82 | GRM7 (0.64) | GRM7P2RX7SCN9ASCN5AKCNH2 | |
| SCHEMBL20113103 | 0.80 | GRM7 (0.65) | GRM7P2RX7KMT2AMEN1 | |
| SCHEMBL20113030 | 0.80 | GRM7 (0.65) | GRM7SCN9ASCN5AKCNH2KMT2A | |
| SCHEMBL20113080 | 0.78 | GRM7 (0.74) | GRM7P2RX7SCN9ASCN5AKCNH2 | |
| SCHEMBL20113106 | 0.77 | GRM7 (0.74) | GRM7SCN9ASCN5AKCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018079862-A1 | MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-03 | — | — | WO | disclosed |