Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19221051 | 0.74 | SIGMAR1 (0.47) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 | |
| SCHEMBL5547924 | 0.68 | KDM1A (0.53) | CYP3A4MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL24716933 | 0.68 | HTR2A (0.47) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 | |
| SCHEMBL414650 | 0.66 | CYP3A4 (0.44) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 | |
| SCHEMBL7790341 | 0.66 | CYP3A4 (0.38) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 | |
| SCHEMBL22393783 | 0.66 | KDM1A (0.42) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 | |
| SCHEMBL315647 | 0.65 | BRD4 (0.54) | TSHRBRD4CREBBP | |
| Hydrochloric Acid SCHEMBL28152573 | 0.64 | CYP3A4 (0.43) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 | |
| Benzene SCHEMBL28485309 | 0.64 | SIGMAR1 (0.44) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 | |
| SCHEMBL1207873 | 0.63 | SIGMAR1 (0.42) | CYP3A4MEN1CYP2D6ALOX15CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10655186-B2 | Point mutations in TRK inhibitor-resistant cancer and methods relating to the same | LOXO ONCOLOGY, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180119228-A1 | POINT MUTATIONS IN TRK INHIBITOR-RESISTANT CANCER AND METHODS RELATING TO THE SAME | ARRAY BIOPHARMA, INC. | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180119228-A1 | POINT MUTATIONS IN TRK INHIBITOR-RESISTANT CANCER AND METHODS RELATING TO THE SAME | NTRK3, NTRK1, NTRK2 | CYP3A4 3407/4885MEN1 2340/4885CYP2D6 3186/4885 |
| US-10655186-B2 | Point mutations in TRK inhibitor-resistant cancer and methods relating to the same | NTRK3, NTRK1, NTRK2 | CYP3A4 3359/4885MEN1 2307/4885CYP2D6 3137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.