Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113350 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113274 | 0.98 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113273 | 0.97 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113272 | 0.96 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113298 | 0.92 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113332 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113339 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113340 | 0.89 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20113336 | 0.89 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL21257015 | 0.88 | ROCK2 (1.00) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039883-A2 | COMPOSITIONS AND METHODS TO TREAT MYELOPROLIFERATIVE DISORDERS AND MYELOPROLIFERATIVE NEOPLASMS | TRANSLATIONAL DRUG DEVELOPMENT LLC (US) | 2024-02-22 | — | — | WO | disclosed |
| EP-3532479-B1 | AMIDE COMPOUNDS AS KINASE INHIBITORS | TRANSLATIONAL DRUG DEV LLC (US) | 2023-06-07 | — | — | EP | disclosed |
| US-20230143583-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2023-05-11 | — | — | US | disclosed |
| US-20230143583-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2023-05-11 | — | — | US | disclosed |
| US-20210047335-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT | TRANSLATIONAL DRUG DEVELOPMENT LLC | 2021-02-18 | — | — | US | disclosed |
| US-10738007-B2 | Amide compounds as kinase inhibitors, compositions and methods of treatment | Translation Drug Development, LLC (US) | 2020-08-11 | — | — | US | disclosed |
| WO-2020142745-A1 | METHODS OF TREATING GRAFT VERSUS HOST DISEASE AND NEOPLASTIC DISEASE WITH AMIDE COMPOUNDS | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-07-09 | — | — | WO | disclosed |
| US-20190248744-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-08-15 | — | — | US | disclosed |
| WO-2018081108-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230143583-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT | ROCK1, ROCK2, ARHGDIB | ROCK2 2/4885ROCK1 1/4885 |
| US-20190248744-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT | ARHGDIB, ROCK2, ROCK1 | ROCK2 2/4885ROCK1 3/4885 |
| US-20210047335-A1 | AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT | ROCK1, ROCK2, ARHGDIB | ROCK2 2/4885ROCK1 1/4885 |
| US-10738007-B2 | Amide compounds as kinase inhibitors, compositions and methods of treatment | ARHGDIB, ROCK2, ROCK1 | ROCK2 2/4885ROCK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.