Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FPR1 | P21462 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20114214 | 0.94 | MAPT (0.54) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20113798 | 0.88 | MAPT (0.52) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20114212 | 0.87 | MAPT (0.61) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20113831 | 0.86 | TP53 (0.56) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20113783 | 0.86 | MAPT (0.54) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20120156 | 0.85 | MAPT (0.49) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20113849 | 0.85 | MAPT (0.47) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20120063 | 0.83 | MAPT (0.51) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20120158 | 0.83 | KDR (0.46) | MAPTPOLBLMNATP53MEN1 | |
| SCHEMBL20113801 | 0.83 | MAPT (0.55) | MAPTPOLBLMNATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081377-A1 | N-PHENYL-2-(3-PHENYL-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)ACETAMIDE DERIVATIVES FOR TREATING CYSTIC FIBROSIS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |