Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | FPR1 | P21462 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 3/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113828 | 0.91 | MAPT (0.39) | MAPTTP53LMNANPC1MAPK1 | |
| SCHEMBL20113785 | 0.88 | TP53 (0.56) | MAPTTP53LMNANPC1MAPK1 | |
| SCHEMBL20113783 | 0.88 | MAPT (0.54) | MAPTTP53LMNANPC1MAPK1 | |
| SCHEMBL20113830 | 0.85 | MAPT (0.49) | MAPTTP53LMNAHTTSMN1; SMN2 | |
| SCHEMBL20114214 | 0.82 | MAPT (0.54) | MAPTTP53LMNAHTTSMN1; SMN2 | |
| SCHEMBL20114212 | 0.81 | MAPT (0.61) | MAPTTP53LMNAKMT2APOLB | |
| SCHEMBL20113831 | 0.81 | TP53 (0.56) | MAPTTP53LMNAKMT2APOLB | |
| SCHEMBL20113789 | 0.81 | TP53 (0.64) | MAPTTP53LMNAKMT2APOLB | |
| SCHEMBL20113782 | 0.78 | TP53 (0.58) | MAPTTP53LMNAMAPK1KMT2A | |
| SCHEMBL20113798 | 0.78 | MAPT (0.52) | MAPTTP53LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081377-A1 | N-PHENYL-2-(3-PHENYL-6-OXO-1,6-DIHYDROPYRIDAZIN-1-YL)ACETAMIDE DERIVATIVES FOR TREATING CYSTIC FIBROSIS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |