Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637456 | 0.91 | PDE10A (0.47) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL16647257 | 0.89 | PDE10A (0.48) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL16647132 | 0.89 | PDE10A (0.48) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL16637062 | 0.89 | PDE10A (0.47) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL16636912 | 0.86 | PDE10A (0.44) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL16637229 | 0.86 | PDE10A (0.47) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL19304137 | 0.82 | PDE10A (0.48) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL16647058 | 0.82 | PDE10A (0.48) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL16636831 | 0.81 | PDE10A (0.46) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL16647244 | 0.81 | PDE10A (0.46) | PDE10ACYP1A2CYP2D6CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370386-B2 | Substituted quinolines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | PDE10A 3998/4885CYP1A2 1845/4885CYP2D6 1911/4885 |
| US-10370386-B2 | Substituted quinolines as inhibitors of KRAS G12C | KRAS, NRAS, HRAS | PDE10A 3944/4885CYP1A2 1511/4885CYP2D6 1699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.