Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17030749 | 0.83 | PDPK1 (0.48) | PDPK1P2RX7ADRA1AADRA1DADRA1B | |
| SCHEMBL19695750 | 0.81 | PDPK1 (0.46) | PDPK1P2RX7ADRA1AADRA1DADRA1B | |
| SCHEMBL27763733 | 0.78 | PDPK1 (0.43) | PDPK1P2RX7ADRA1AADRA1DADRA1B | |
| SCHEMBL3058083 | 0.77 | ALDH1A1 (0.51) | PDPK1P2RX7RAB9AALDH1A1TDP1 | |
| SCHEMBL17194980 | 0.76 | ADORA2A (0.42) | PDPK1P2RX7ADRA1AADRA1DADRA1B | |
| SCHEMBL5692672 | 0.75 | PDPK1 (0.64) | PDPK1ADRA1AADRA1DADRA1BRAB9A | |
| SCHEMBL1047236 | 0.74 | PDPK1 (0.53) | PDPK1ADRA1AADRA1DADRA1BRAB9A | |
| SCHEMBL5014843 | 0.73 | PDPK1 (0.48) | PDPK1ADRA1AADRA1DADRA1BRAB9A | |
| SCHEMBL1951149 | 0.73 | PDPK1 (0.61) | PDPK1ADRA1AADRA1DADRA1BRAB9A | |
| SCHEMBL996777 | 0.71 | PDPK1 (0.53) | PDPK1ADRA1AADRA1DADRA1BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370386-B2 | Substituted quinolines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | PDPK1 891/4885P2RX7 3188/4885ADRA1A 568/4885 |
| US-10370386-B2 | Substituted quinolines as inhibitors of KRAS G12C | KRAS, NRAS, HRAS | PDPK1 1588/4885P2RX7 2908/4885ADRA1A 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.