⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25144494 | 0.78 | — | — | |
| SCHEMBL269699 | 0.72 | ADH1A (0.40) | — | |
| SCHEMBL270491 | 0.72 | — | — | |
| SCHEMBL19635304 | 0.72 | — | — | |
| SCHEMBL8078492 | 0.67 | — | — | |
| SCHEMBL5445548 | 0.67 | — | — | |
| SCHEMBL5445544 | 0.67 | — | — | |
| SCHEMBL24806925 | 0.67 | CA12 (0.30) | — | |
| SCHEMBL14401647 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL22575470 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002394-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | AKARNA THERAPEUTICS, LTD. (GB) | 2023-01-05 | — | — | US | disclosed |
| US-20210214362-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | AKARNA THERAPEUTICS, LTD. (GB) | 2021-07-15 | — | — | US | disclosed |
| US-10421759-B2 | Fused bicyclic compounds for the treatment of disease | AKARNA THERAPEUTICS, LTD. (GB) | 2019-09-24 | — | — | US | disclosed |
| US-20180118752-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE | AKARNA THERAPEUTICS, LTD. | 2018-05-03 | — | — | US | disclosed |