ADH1A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL39255	0.94	14/20
SCHEMBL59918	0.41	13/20
SCHEMBL329469	0.41	13/20
SCHEMBL493755	0.41	13/20
SCHEMBL536191	0.59	12/20
SCHEMBL528874	0.54	12/20
SCHEMBL411186	0.46	10/20
SCHEMBL15013	0.50	8/20
SCHEMBL283931	0.50	8/20
SCHEMBL612785	0.50	8/20
SCHEMBL612962	0.50	8/20
SCHEMBL296264	0.52	7/20
SCHEMBL303776	1.00	6/20
SCHEMBL23038	0.50	6/20
SCHEMBL304405	0.50	6/20
SCHEMBL460664	0.50	6/20
SCHEMBL245391	1.00	5/20
SCHEMBL645299	1.00	5/20
SCHEMBL302803	0.61	5/20
SCHEMBL150343	0.50	5/20

Clinical trials — most relevant to ADH1A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes	PHASE4	COMPLETED
Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor	PHASE2	COMPLETED
Pharmacogenetic Study of Ondansetron in Alcohol Use Disorder	PHASE2	COMPLETED
A Novel Pharmacotherapy for Alcoholism and Alcohol Liver Disease	PHASE2	COMPLETED
Predicting Alcoholics' Treatment Responses to a Selective Serotonin Re-uptake Inhibitor (SSRI)	PHASE2	COMPLETED
Non-oxidative Metabolite Profiles After Increasing Doses of Ethanol	PHASE1	COMPLETED
Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease	PHASE1	NOT_YET_RECRUITING
The Objective of This Phase 1 Study is to Evaluate the Food Effect of 100 mg Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fed Versus 100 mg of Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fasted Conditions in Healthy Adult Male Subjects	PHASE1	RECRUITING
Nicotinic Receptor Genetic Variation and Alcohol Reward	PHASE1	RECRUITING
Study to Compare the Effects of Viagra® Vs Hezkue® in Healthy Fasted Male Participants.	PHASE1	NOT_YET_RECRUITING
ALDH2 Genetic Testing in East Asian Community	nan	NOT_YET_RECRUITING
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China	nan	COMPLETED
Alcohol Metabolism and Disease Risk in Asians	nan	COMPLETED
Bipolar Disorder With Alcoholism in Han Chinese	nan	UNKNOWN
Hepatic Lipid Metabolism-Alcohol Use Disorder	nan	RECRUITING
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients	nan	RECRUITING
Dose-response Effect of Alcohol Ingestion on Steroid Profile	nan	COMPLETED
Clinical-Genetic Variation in GABA/Alcohol Sensitivity	nan	COMPLETED
Alterations of Gut Microbiota and Metabolites in ALD Patients	nan	UNKNOWN
Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)	nan	COMPLETED
Adrenoleukodystrophy National Registry Study	nan	RECRUITING
Biobehavioral Pathways Underlying Alcohol Use and Health	nan	COMPLETED
Alcoholic Liver Disease and the Gut Microbiome	nan	ACTIVE_NOT_RECRUITING
Validation in Humans of Genes Involved in Alcohol Drinking, Stress-Induced Alcohol Drinking and Relapse	nan	COMPLETED
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics	nan	RECRUITING
Pharmacogenetics of Alcohol: Treatment Implications	nan	COMPLETED
Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation	nan	COMPLETED
Complex Exploratory Study of Alcohol-Associated Hepatitis	nan	UNKNOWN
Integrated Approaches for Identifying Molecular Targets in Alcoholic Hepatitis	nan	COMPLETED
Biomarkers for the Detection of Heavy Alcohol Use in Patients With and Without Liver Disease	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADH1A binder may also engage these)

Protein	Name	Similarity
ADH1C	Alcohol dehydrogenase 1C	1.000	landscape →
Q5RBP7	—	1.000	Q5RBP7 →
O97959	—	1.000	O97959 →
P00328	—	1.000	P00328 →
P86885	—	1.000	P86885 →
P28469	—	1.000	P28469 →
P80338	—	1.000	P80338 →
P00329	—	1.000	P00329 →
P14139	—	1.000	P14139 →
Q5R1W2	—	1.000	Q5R1W2 →
Q64415	—	1.000	Q64415 →
P19631	—	1.000	P19631 →
P00327	—	1.000	P00327 →
ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	1.000	landscape →
P23991	—	1.000	P23991 →
P86883	—	1.000	P86883 →
P80222	—	1.000	P80222 →
Q03505	—	1.000	Q03505 →
P80512	—	1.000	P80512 →
P49645	—	1.000	P49645 →
P22797	—	1.000	P22797 →
O19053	—	1.000	O19053 →
P93629	—	0.999	P93629 →
P41680	—	0.999	P41680 →
P81601	—	0.999	P81601 →
P19854	—	0.999	P19854 →
P28474	—	0.999	P28474 →
Q3ZC42	—	0.998	Q3ZC42 →
Q64437	—	0.998	Q64437 →
Q9Z2M2	—	0.997	Q9Z2M2 →