Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MGLL | Q99685 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12259200 | 0.82 | TDP1 (0.81) | KMT2AALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL19419916 | 0.81 | TSHR (0.70) | ALDH1A1SMN1; SMN2NPSR1TDP1ATM | |
| SCHEMBL20116457 | 0.79 | POLB (0.78) | KMT2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL20116234 | 0.79 | ALDH1A1 (0.63) | KMT2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL11751984 | 0.78 | NPC1 (0.54) | KMT2AALDH1A1SMN1; SMN2NPSR1TDP1 | |
| SCHEMBL30157791 | 0.73 | GAA (0.63) | KMT2AALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL10202314 | 0.72 | TSHR (0.71) | KMT2AALDH1A1ATML3MBTL1NPC1 | |
| SCHEMBL19836108 | 0.72 | ALDH1A1 (0.66) | KMT2AALDH1A1MAPTTDP1ATM | |
| SCHEMBL30158578 | 0.71 | ALDH1A1 (0.60) | KMT2AALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20116142 | 0.71 | POLB (0.60) | KMT2AALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |