Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116882 | 1.00 | PDE1A (0.44) | PDE1APDE1BPDE1CPIK3CDPDE4D | |
| SCHEMBL20116287 | 1.00 | PDE1A (0.44) | PDE1APDE1BPDE1CPIK3CDPDE4D | |
| SCHEMBL20676205 | 0.92 | JAK1 (0.40) | PDE1APDE1BPDE1CPIK3CDCHRM2 | |
| SCHEMBL19703352 | 0.92 | PDE1A (0.51) | PDE1APDE1BPDE1CPIK3CDPDE4D | |
| SCHEMBL20116574 | 0.88 | PDE1B (0.40) | PDE1APDE1BPDE1CPIK3CDCHRM2 | |
| SCHEMBL13432160 | 0.84 | KMO (0.43) | PDE1APDE1BPDE1CPIK3CDCHRM2 | |
| SCHEMBL22358058 | 0.83 | PIK3CD (0.41) | PDE1APDE1BPDE1CPIK3CDPDE4D | |
| SCHEMBL20676295 | 0.83 | PIK3CD (0.42) | PDE1APDE1BPDE1CPIK3CDPDE4D | |
| SCHEMBL22358076 | 0.83 | PIK3CD (0.41) | PDE1APDE1BPDE1CPIK3CDPDE4D | |
| SCHEMBL26997324 | 0.83 | PIK3CD (0.42) | PDE1APDE1BPDE1CPIK3CDPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |