Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 5/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830331 | 0.88 | KDM1A (0.44) | KHKKMOHTR2AHTR2CHTR2B | |
| SCHEMBL13432160 | 0.85 | KMO (0.43) | KMOKDM1ACHRM2CHRM1CHRM3 | |
| SCHEMBL15830291 | 0.85 | KDM1A (0.51) | KHKKMOKDM1ACHRM2CHRM1 | |
| SCHEMBL17678157 | 0.83 | KMO (0.41) | KMOKDM1ACHRM2CHRM1CHRM3 | |
| SCHEMBL26811385 | 0.81 | HTR2A (0.44) | KHKHTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL20116574 | 0.81 | PDE1B (0.40) | KMOCHRM2CHRM1CHRM3HTR1A | |
| SCHEMBL20116866 | 0.81 | KMO (0.43) | KHKKMOCHRM2CHRM1CHRM3 | |
| SCHEMBL26997309 | 0.81 | KDM5A (0.39) | KHKCHRNB2CHRNA4HTR1AHTR1B | |
| SCHEMBL22358062 | 0.81 | SCD (0.39) | KHKHTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL26811388 | 0.81 | HTR2C (0.46) | HTR2AHTR2CHTR2BCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |