Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 2/20 | 0.37 |
| ▸ | CCND3 | P30281 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116464 | 0.85 | POLB (0.44) | MAPTKMT2AGAAMEN1KDM4E | |
| SCHEMBL30405324 | 0.84 | MAPT (0.42) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL21414320 | 0.81 | HRH4 (0.44) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL10255132 | 0.81 | MAPT (0.46) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL21414367 | 0.80 | MAPT (0.43) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL22159076 | 0.78 | MAPT (0.47) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL6883104 | 0.76 | MAPT (0.49) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL23707095 | 0.75 | MAPT (0.42) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL10256822 | 0.75 | CHKA (0.48) | MAPTHTR3AKMT2AGAAMEN1 | |
| SCHEMBL23916695 | 0.73 | HRH3 (0.42) | MAPTHTR3AKMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081294-A1 | PYRAZOLE AMIDE COMPOUNDS AS IRAK INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |