Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116508 | 0.85 | MAPT (0.40) | MAPTALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL10255058 | 0.81 | POLB (0.51) | POLBPCSK9MAPTALDH1A1KDM4E | |
| SCHEMBL21003967 | 0.80 | ALDH1A1 (0.49) | POLBMAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL22538747 | 0.79 | POLB (0.49) | POLBPCSK9MAPTALDH1A1KDM4E | |
| SCHEMBL23104156 | 0.76 | POLB (0.47) | POLBPCSK9MAPTALDH1A1KDM4E | |
| SCHEMBL13549935 | 0.76 | MAPT (0.45) | MAPTSMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL23108639 | 0.74 | POLB (0.45) | POLBPCSK9MAPTALDH1A1KDM4E | |
| SCHEMBL20582235 | 0.73 | POLB (0.47) | POLBPCSK9MAPTALDH1A1KDM4E | |
| SCHEMBL5391233 | 0.72 | ALDH1A1 (0.47) | POLBMAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL807518 | 0.72 | POLB (0.51) | POLBPCSK9MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212523-A1 | PYRAZOLE AMIDE COMPOUNDS AS IRAK INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2018081294-A1 | PYRAZOLE AMIDE COMPOUNDS AS IRAK INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |