Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | SMO | Q99835 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116646 | 0.91 | HTT (0.59) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL20116204 | 0.90 | HTT (0.58) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL30506238 | 0.89 | HTT (0.58) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL20660764 | 0.89 | HTT (0.58) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL20116341 | 0.86 | HTT (0.57) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL20116121 | 0.86 | TSHR (0.71) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL20660946 | 0.86 | SMO (0.56) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL20116343 | 0.84 | TSHR (0.65) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL20116344 | 0.84 | SMO (0.53) | HTTTSHRMEN1CYP3A4CYP2C9 | |
| SCHEMBL20117193 | 0.83 | SMO (0.55) | HTTTSHRMEN1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |