Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 6/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | PDE4A | P27815 | 5/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 1/20 | 0.55 |
| ▸ | F7 | P08709 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368852 | 0.88 | PRSS1 (0.77) | PRSS1MAPK1TSHRGAAPRSS2 | |
| SCHEMBL5306761 | 0.87 | PRSS1 (0.82) | PRSS1MAPK1F2HPGD | |
| SCHEMBL5326585 | 0.87 | PRSS1 (1.00) | PRSS1F2 | |
| Hydrochloric Acid SCHEMBL6287246 | 0.86 | PRSS1 (0.77) | PRSS1TSHRPRSS2PRSS3HPGD | |
| SCHEMBL14599629 | 0.85 | PRSS1 (1.00) | PRSS1F2 | |
| SCHEMBL14599546 | 0.84 | PRSS1 (0.72) | PRSS1MAPK1TSHRKDM4E | |
| SCHEMBL6944861 | 0.83 | MAPK1 (1.00) | MAPK1TSHRPDE4APDE4BPDE4C | |
| SCHEMBL10143584 | 0.83 | PRSS1 (0.62) | PRSS1MAPK1TSHRMAPTALDH1A1 | |
| SCHEMBL12461546 | 0.83 | PRSS1 (0.85) | PRSS1F2 | |
| SCHEMBL13127138 | 0.83 | PRSS1 (0.61) | PRSS1MAPK1F2F10F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12275723-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2025-04-15 | — | — | US | disclosed |
| US-20240124435-A1 | COMPOUNDS AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2024-04-18 | — | — | US | disclosed |
| EP-3700934-A1 | COMPOUNDS AND USES THEREOF | Yumanity Therapeutics, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124435-A1 | COMPOUNDS AND USES THEREOF | NLN, ACHE, CLN6 | PRSS1 1923/4885MAPK1 4304/4885TSHR 4679/4885 |
| US-12275723-B2 | Compounds and uses thereof | NLN, ACHE, CLN6 | PRSS1 1923/4885MAPK1 4304/4885TSHR 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.