Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 3/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22357746 | 0.85 | KMO (0.37) | KMOPTGER3HTR2AHTR2CPTGS1 | |
| SCHEMBL19699718 | 0.80 | KMO (0.45) | CHRM2CHRM1CHRM3KMOPTGER3 | |
| SCHEMBL20117060 | 0.76 | KMO (0.44) | CHRM2CHRM1CHRM3KMOCYP1A2 | |
| SCHEMBL20117056 | 0.75 | KMO (0.48) | CHRM2CHRM1CHRM3KMOCYP1A2 | |
| SCHEMBL20117061 | 0.74 | KMO (0.50) | CHRM2CHRM1CHRM3KMOCYP1A2 | |
| SCHEMBL20117057 | 0.74 | KMO (0.47) | CHRM2CHRM1CHRM3KMOCYP1A2 | |
| SCHEMBL14250555 | 0.74 | HDAC8 (0.42) | HTR2AHTR2CHDAC8SLC6A4POLB | |
| SCHEMBL20676290 | 0.72 | KMO (0.48) | CHRM2CHRM1CHRM3KMOHTR2A | |
| SCHEMBL13432160 | 0.71 | KMO (0.43) | CHRM2CHRM1CHRM3KMOCYP11B2 | |
| SCHEMBL20676291 | 0.70 | KMO (0.43) | CHRM2CHRM1CHRM3KMOHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |