SCHEMBL20117022

SCHEMBL20117022

CC1CCCN(c2cc(C(N)=O)nc(-c3ccc(Oc4ccc(F)cc4)cc3)n2)C1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 20/20 0.80
SCN9A Q15858 19/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14743534 0.89 SCN9A (1.00) FPR2SCN9A
SCHEMBL18798948 0.88 FPR2 (0.82) FPR2SCN9A
SCHEMBL19956171 0.87 SCN9A (0.77) FPR2SCN9A
SCHEMBL19072096 0.87 SCN9A (0.77) FPR2SCN9A
SCHEMBL19072283 0.85 SCN9A (0.78) FPR2SCN9A
SCHEMBL19956193 0.85 SCN9A (0.81) FPR2SCN9A
SCHEMBL22779640 0.85 FPR2 (0.79) FPR2SCN9A
SCHEMBL19072317 0.83 SCN9A (1.00) FPR2SCN9A
SCHEMBL14743902 0.83 SCN9A (1.00) FPR2SCN9A
SCHEMBL22779559 0.83 SCN9A (1.00) FPR2SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2964639-B1 PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS PURDUE PHARMA LP (US) 2018-05-02 EP disclosed