Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16013421 | 0.89 | SCN9A (0.60) | SCN9AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL16012982 | 0.89 | SCN9A (0.60) | SCN9AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3717819 | 0.84 | SCN9A (0.51) | SCN9AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3727036 | 0.84 | SCN9A (0.51) | SCN9AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3727334 | 0.84 | SCN9A (0.51) | SCN9AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL19956218 | 0.84 | JAK2 (0.42) | SCN9AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL19956223 | 0.84 | FPR2 (0.66) | SCN9AFPR2 | |
| SCHEMBL19956217 | 0.81 | SCN9A (0.51) | SCN9AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL1734370 | 0.80 | KDM4E (0.74) | SCN9AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL16012691 | 0.75 | SCN9A (0.83) | SCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964639-B1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2018-05-02 | — | — | EP | disclosed |