Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ATIC | P31939 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2237776 | 0.83 | CA1 (0.60) | CYP19A1GPR27PTGES2MEN1KMT2A | |
| SCHEMBL10093407 | 0.81 | ATIC (0.58) | CYP19A1GPR27MEN1KMT2AAVPR2 | |
| SCHEMBL2237042 | 0.80 | CYP19A1 (0.58) | CYP19A1GPR27PTGES2GAAMEN1 | |
| SCHEMBL2236105 | 0.80 | CYP19A1 (0.58) | CYP19A1GPR27PTGES2MEN1PKM | |
| SCHEMBL2234339 | 0.79 | CYP19A1 (0.57) | CYP19A1GPR27MEN1KMT2AAVPR2 | |
| SCHEMBL15232983 | 0.79 | CYP19A1 (0.57) | CYP19A1GPR27MEN1PKMKMT2A | |
| SCHEMBL2235467 | 0.79 | POLB (0.70) | CYP19A1GPR27MEN1KMT2APOLB | |
| SCHEMBL2234325 | 0.78 | CYP19A1 (0.56) | CYP19A1GPR27GAAMEN1KMT2A | |
| SCHEMBL13464221 | 0.78 | CYP19A1 (0.56) | CYP19A1GPR27PTGES2HPGDMEN1 | |
| SCHEMBL2896014 | 0.78 | CYP19A1 (0.56) | CYP19A1GPR27AVPR2ALOX15HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349990-B1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | PIMCO 2664 LTD (GB) | 2018-05-02 | — | — | EP | disclosed |