Sugi Predict

Sugi Predict / Targets / ATIC

ATIC

Bifunctional purine biosynthesis protein ATIC · P31939 · ATIC on Sugi Atlas →

16,932 patent compounds predicted against ATIC, 13,142 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1065440 SCHEMBL1065440 0.55 5/20
SCHEMBL1065450 SCHEMBL1065450 0.55 5/20
Lometrexol Lometrexol (SCHEMBL14365) 0.71 4/20
Folic Acid Folic Acid (SCHEMBL454201) 0.61 4/20
Lometrexol Lometrexol (SCHEMBL18530) 0.60 4/20
Folitixorin Folitixorin (SCHEMBL50782) 0.56 4/20
Arfolitixorin Arfolitixorin (SCHEMBL186747) 0.56 4/20
Folitixorin Folitixorin (SCHEMBL258730) 0.56 4/20
SCHEMBL133543 SCHEMBL133543 0.56 4/20
SCHEMBL8060 SCHEMBL8060 0.55 4/20
SCHEMBL8061 SCHEMBL8061 0.55 4/20
SCHEMBL258465 SCHEMBL258465 0.55 4/20
SCHEMBL422934 SCHEMBL422934 0.53 4/20
SCHEMBL973923 SCHEMBL973923 0.52 4/20
Dihydrofolic Acid Dihydrofolic Acid (SCHEMBL132019) 0.51 4/20
SCHEMBL573199 SCHEMBL573199 0.51 4/20
SCHEMBL50298 SCHEMBL50298 0.51 4/20
SCHEMBL716106 SCHEMBL716106 0.51 4/20
Levomefolic Acid Levomefolic Acid (SCHEMBL79586) 0.50 4/20
SCHEMBL1071860 SCHEMBL1071860 0.47 4/20

Clinical trials — most relevant to ATIC by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Intervention of Multi-vitamin With Minerals to Hyperuricemia PHASE4UNKNOWN
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
Efficacy of Oral Tofacitinib in Moderate to Severe Alopecia Areata, Totalis and Universalis at Tertiary Care Hospital, Karachi. PHASE3COMPLETED
Preventing Acute Kidney Injury (AKI) in Pediatric Patients PHASE3UNKNOWN
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia PHASE2COMPLETED
A Study to Assess APO866 for the Treatment of Advanced Melanoma PHASE2COMPLETED
Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer PHASE2RECRUITING
Arsenic Trioxide in Refractory Solid Tumors With Rescuable p53 Mutation PHASE2UNKNOWN
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
The Relationship Between Uric Acid and Inflammatory Markers PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
A Phase I Trial of SHR3162 in Subjects With Advanced Solid Tumors PHASE1COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Elucidating the Molecular and Biochemical Basis of the Human AhR-mutation Disease nanUNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome nanUNKNOWN
Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19 nanUNKNOWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Sirtuin1 in COVID19 Patients nanUNKNOWN
Alternative Substrates in the Critically Ill Subject nanCOMPLETED
Effect of Acute Fructose Load in Human nanCOMPLETED
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ATIC binder may also engage these)

ProteinNameSimilarity
Q9CWJ9 — 1.000 Q9CWJ9 →
Q5R5C2 — 1.000 Q5R5C2 →
J9VJP1 — 0.999 J9VJP1 →
Q0VCK0 — 0.999 Q0VCK0 →
O74928 — 0.998 O74928 →
P31335 — 0.995 P31335 →
O35567 — 0.995 O35567 →
P54113 — 0.994 P54113 →
P38009 — 0.991 P38009 →
A4SDE6 — 0.985 A4SDE6 →
O93918 — 0.985 O93918 →
Q9UUE1 — 0.984 Q9UUE1 →
Q9I7S8 — 0.984 Q9I7S8 →
Q1WU55 — 0.984 Q1WU55 →
Q9CFG0 — 0.984 Q9CFG0 →
Q98ES7 — 0.984 Q98ES7 →
A1BE85 — 0.984 A1BE85 →
B3EEI0 — 0.984 B3EEI0 →
B9JEU9 — 0.984 B9JEU9 →
C5CL84 — 0.984 C5CL84 →
Q8X1T3 — 0.984 Q8X1T3 →
Q6G5S5 — 0.984 Q6G5S5 →
Q3B5R1 — 0.984 Q3B5R1 →
P45353 — 0.984 P45353 →
A8AUA2 — 0.983 A8AUA2 →
A4VYK5 — 0.983 A4VYK5 →
Q92210 — 0.983 Q92210 →
B7KGS0 — 0.983 B7KGS0 →
P32327 — 0.983 P32327 →
A8NEP3 — 0.983 A8NEP3 →