Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 12/20 | 0.77 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.77 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.77 |
| ▸ | JAK2 | O60674 | 2/20 | 0.77 |
| ▸ | ABL1 | P00519 | 2/20 | 0.77 |
| ▸ | INSR | P06213 | 2/20 | 0.77 |
| ▸ | LCK | P06239 | 2/20 | 0.77 |
| ▸ | FYN | P06241 | 2/20 | 0.77 |
| ▸ | YES1 | P07947 | 2/20 | 0.77 |
| ▸ | LYN | P07948 | 2/20 | 0.77 |
| ▸ | RET | P07949 | 2/20 | 0.77 |
| ▸ | MET | P08581 | 2/20 | 0.77 |
| ▸ | ROS1 | P08922 | 2/20 | 0.77 |
| ▸ | KIT | P10721 | 2/20 | 0.77 |
| ▸ | SRC | P12931 | 2/20 | 0.77 |
| ▸ | BRAF | P15056 | 2/20 | 0.77 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014363 | 0.96 | FGFR1 (0.84) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| SCHEMBL2013451 | 0.92 | FGFR3 (0.91) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| SCHEMBL374711 | 0.87 | FGFR3 (1.00) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| Infigratinib SCHEMBL374435 | 0.87 | FGFR3 (1.00) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| SCHEMBL374257 | 0.85 | FGFR3 (0.88) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| SCHEMBL16383021 | 0.85 | FGFR3 (0.92) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| SCHEMBL19338005 | 0.84 | FGFR3 (0.91) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| SCHEMBL2011033 | 0.84 | FGFR3 (0.91) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| Infigratinib SCHEMBL14893408 | 0.84 | FGFR3 (1.00) | FGFR1FGFR3FGFR4CYP3A4FGFR2 | |
| SCHEMBL2014816 | 0.84 | FGFR1 (0.83) | FGFR1FGFR3FGFR4CYP3A4FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976847-B1 | PYRIMIDINYL ARYL UREA DERIVATIVES BEING FGF INHIBITORS | NOVARTIS AG (CH) | 2015-06-17 | — | — | EP | claimed |
| CN-101336237-A | Pyrimidinyl aryl urea derivatives being fgf inhibitors | NOVARTIS AG (CH) | 2008-12-31 | — | — | CN | claimed |
| US-20080312248-A1 | Pyrimidinyl Aryl Urea Derivatives Being Fgf Inhibitors | NOVARTIS AG | 2008-12-18 | — | — | US | claimed |
| EP-1976847-B1 | PYRIMIDINYL ARYL UREA DERIVATIVES BEING FGF INHIBITORS | NOVARTIS AG (CH) | 2015-06-17 | — | — | EP | disclosed |
| US-8759517-B2 | Pyrirnidinyl aryl urea derivatives being FGF inhibitors | NOVARTIS AG (CH) | 2014-06-24 | — | — | US | disclosed |
| US-20130030171-A1 | Pyrimidinyl Aryl Urea Derivatives being FGF Inhibitors | NOVARTIS AG (CH) | 2013-01-31 | — | — | US | disclosed |
| EP-2512476-A1 | METHOD FOR TREATING HAEMATOLOGICAL CANCERS | Novartis AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| US-8293746-B2 | Pyrimidinyl aryl urea derivatives being FGF inhibitors | NOVARTIS AG (CH) | 2012-10-23 | — | — | US | disclosed |
| US-20120258940-A1 | METHOD FOR TREATING HAEMATOLOGICAL CANCERS | NOVARTIS AG (CH) | 2012-10-11 | — | — | US | disclosed |
| WO-2011075620-A1 | METHOD FOR TREATING HAEMATOLOGICAL CANCERS | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| US-20080312248-A1 | Pyrimidinyl Aryl Urea Derivatives Being Fgf Inhibitors | NOVARTIS AG | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258940-A1 | METHOD FOR TREATING HAEMATOLOGICAL CANCERS | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR3 1/4885FGFR4 5/4885 |
| US-20080312248-A1 | Pyrimidinyl Aryl Urea Derivatives Being Fgf Inhibitors | FGFR1, FGF1, FGF2 | FGFR1 1/4885FGFR3 5/4885FGFR4 6/4885 |
| US-20130030171-A1 | Pyrimidinyl Aryl Urea Derivatives being FGF Inhibitors | FGFR1, FGF1, FGF2 | FGFR1 1/4885FGFR3 5/4885FGFR4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.