Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.58 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CBLB | Q13191 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919977 | 1.00 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9ASTING1 | |
| SCHEMBL2016006 | 0.87 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9AHSD17B10 | |
| SCHEMBL2013911 | 0.84 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AKDM4E | |
| SCHEMBL2011800 | 0.84 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2015191 | 0.84 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2010237 | 0.84 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AHSD17B10 | |
| SCHEMBL2010795 | 0.82 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AMAPT | |
| SCHEMBL2015844 | 0.82 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2054013 | 0.82 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AMAPT | |
| SCHEMBL2012888 | 0.82 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |