Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22364357 | 0.86 | CTSK (0.50) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL22364358 | 0.86 | CTSK (0.50) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL20118765 | 0.86 | CTSK (0.50) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL18075261 | 0.85 | CTSK (0.49) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL18075467 | 0.85 | CTSK (0.49) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL21332796 | 0.85 | CTSK (0.49) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL21332799 | 0.85 | CTSK (0.49) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL18075260 | 0.85 | CTSK (0.49) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL21340817 | 0.85 | CTSK (0.49) | CTSKCTSSCA2CA1CA7 | |
| SCHEMBL18075034 | 0.85 | CTSK (0.49) | CTSKCTSSCA2CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081513-A1 | PRODRUGS OF KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |