SCHEMBL20118871

SCHEMBL20118871

Nc1nc(Cl)c2cnn(Cc3ccc4c(c3)OCO4)c2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TRAP1 Q12931 7/20 1.00
HSP90AA1 P07900 6/20 1.00
HSP90B1 P14625 3/20 0.69
HSP90AB1 P08238 3/20 0.53
ADORA2A P29274 5/20 0.46
ADORA1 P30542 5/20 0.46
SLC2A1 P11166 1/20 0.44
PDE9A O76083 1/20 0.44
CMA1 P23946 1/20 0.44
PDE1C Q14123 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20118818 0.84 HSP90AA1 (0.79) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL20118704 0.83 HSP90AA1 (0.78) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL20118703 0.82 HSP90AA1 (0.76) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL20118580 0.82 HSP90AA1 (1.00) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL3394461 0.81 TRAP1 (0.67) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL25546964 0.80 HSP90AA1 (0.66) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL20118702 0.79 TRAP1 (0.65) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL20118865 0.78 HSP90AA1 (0.68) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL20118840 0.78 HSP90AA1 (0.63) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A
SCHEMBL20118740 0.78 TRAP1 (0.64) TRAP1HSP90AA1HSP90B1HSP90AB1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018079988-A1 COMPOUND USEFUL AS TRAP1 INHIBITOR, AND ANTICANCER COMPOSITION CONTAINING SAME 울산과학기술원 2018-05-03 WO disclosed