Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.48 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119453 | 0.92 | HSD11B1 (0.54) | HSD11B1PIK3CGPIK3CDPIK3CASMPD3 | |
| SCHEMBL20119112 | 0.81 | SMPD3 (0.47) | SMPD3 | |
| SCHEMBL20119368 | 0.80 | SMPD3 (0.43) | PIK3CGPIK3CDPIK3CASMPD3NTRK1 | |
| SCHEMBL20119117 | 0.79 | NTRK1 (0.72) | NTRK1JAK2 | |
| SCHEMBL20119158 | 0.79 | NTRK1 (0.72) | NTRK1JAK2 | |
| SCHEMBL21313052 | 0.79 | NTRK1 (0.72) | NTRK1JAK2 | |
| SCHEMBL19560179 | 0.79 | NTRK1 (0.63) | HSD11B1NTRK1JAK2 | |
| SCHEMBL20119340 | 0.78 | SMPD3 (0.51) | SMPD3JAK2 | |
| SCHEMBL20119441 | 0.78 | SMPD3 (0.51) | SMPD3JAK2 | |
| SCHEMBL21319568 | 0.78 | SMPD3 (0.50) | SMPD3NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3533796-B1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| WO-2018077246-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | 正大天晴药业集团股份有限公司 | 2018-05-03 | — | — | WO | disclosed |