Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.41 |
| ▸ | RET | P07949 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119346 | 0.80 | NTRK1 (0.62) | — | |
| SCHEMBL20119921 | 0.80 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL20119425 | 0.76 | PIK3CG (0.53) | IRAK4PIK3CAPIK3CG | |
| SCHEMBL23607512 | 0.67 | DYRK1A (0.49) | GSK3BDYRK1AIRAK4RET | |
| SCHEMBL23580652 | 0.66 | GSK3B (0.46) | GSK3BDYRK1ARET | |
| SCHEMBL30340810 | 0.66 | GSK3B (0.46) | GSK3BDYRK1ARET | |
| SCHEMBL23580326 | 0.66 | GSK3B (0.48) | GSK3BDYRK1ARETPIK3CG | |
| SCHEMBL14050908 | 0.66 | TYK2 (0.39) | GSK3BDYRK1A | |
| SCHEMBL15182839 | 0.64 | GSK3B (0.51) | GSK3BDYRK1A | |
| SCHEMBL30753644 | 0.64 | DYRK1A (0.53) | GSK3BDYRK1AIRAK4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3533796-B1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3533796-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-09-04 | — | — | EP | disclosed |
| WO-2018077246-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | 正大天晴药业集团股份有限公司 | 2018-05-03 | — | — | WO | disclosed |